12/26/2023 0 Comments Grand dragon roger kelly![]() ![]() The dual acting anthraquinone Alchemix induces cell death independently ATM and p53. R., Weston V.J., Stankovic T., Kearns P., Pors K., Grand R.J., StewartG.S. Thomas A., Perry T., Berhane S., Oldreive C., Zlatanou A., Williams L. (2014) ATM activation in hypoxia-causes and consequences. Hollingworth R, Skalka GL, Stewart GS, Hislop AD, Blackbourn DJ, Grand RJ.(2015) Activation of DNA Damage Response Pathways during Lytic Replication of KSHV Viruses 7(6):2908-27. (2015) Modulation of DNA damage and repair pathways by human tumour viruses. Viruses. (2016) Activation of the DNA damage resp[onse by RNA viruses Biomolecules. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. Hollingworth R, Horniblow RD, Forrest C, Stewart GS, Grand RJ. Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection.J Virol. doi: 10.1128/JVI.01268-20Ĭhalabi Hagkarim N, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ. (2020) Structural Determinants within the Adenovirus Early Region 1A Protein Spacer Region Necessary for Tumorigenesis. (2020) Productive herpesvirus lytic replication in primary effusion lymphoma cells requires S-phase entry. (2020) The Regulatory Properties of the Ccr4-Not Complex.Cells. Charitable donations through the University of Birmingham, justgiving.Ĭhalabi Hagkarim N, Grand RJ. The role of the adenovirus E1B55K protein. The CNOT complex seems to function in the cellular response to DNA replication stress-this is also an ongoing project. To what extent this is related to a role in the DNA damage response is not clear at present and is the subject of ongoing investigation. ![]() It has been found that the hnRNPUL1 gene is mutated in a number of inherited diseases such as ALS and early onset myocardial infarction. This work has concentrated on the characterization of relatively recently isolated DNA damage response proteins hnRNPUL-1 (also known as E1B-AP5), Tab182, and the CNOT complex, all of which appear to function in RNA metabolism, transcriptional regulation and, importantly, the DNA damage response. Over the last ten years RG has developed an interest in the DNA damage response, in both adenovirus and KSHV infected cells and in the absence of viral infection. Thus, RG has also published research papers dealing with the properties of p53, the retinoblastoma protein Rb, Ras, C-terminal binding protein (CtBP), C-terminal binding protein interacting protein (CtIP) and hnRNPUL-1. While this has led to considerable progress in our understanding of the modes of action of the E1 proteins – in particular, the E1A and E1B55K oncoproteins it has also helped in our understanding of various cellular pathways which are affected during viral infection or cellular transformation. Roger Grand’s (RG) main research interest for the past thirty years has been in adenovirus virology with particular emphasis on the roles of the early region1 (E1) proteins in viral infection and in adenovirus-mediated cell transformation. He now is an honorary member of staff but continues to work full time. He has also worked on, and has a continued interest in, KSHV. At present his main interest is in the CNOT complex and its relationship to DNA replication stress. They directed the group together until Phil Gallimore retired, since which time Roger has led a group, mainly focussed on adenovirus research, but latterly with a considerable interest in its relationship to the DNA damage response. After a short post-doctoral fellowship at the University of London (Royal Holloway College) he joined Professor Sam Perry’s ‘muscle research group’ in the Department of Biochemistry in Birmingham.Ī decade later Roger changed tack and moved to the Department of Cancer Studies to join the `adenovirus research group’ with Professor Phil Gallimore. in biochemistry at the University of Sheffield, in a department much influenced by Professor Hans Krebs. ![]()
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